For the first time, hyperbaric oxygen therapy was shown to reverse biological aging in humans. A landmark study by researchers in Israel has found that hyperbaric oxygen therapy (HBOT) reverses two key biological signs of aging in humans – the first study to find that. Research shows that it is possible to target and reverse the aging process at a basic biological-cellular level.

Hyperbaric oxygen therapy

This breakthrough in aging biology research provides a new foundation for scientists to investigate ways to slow the aging process. Published in the peer-reviewed journal Aging, the study involved patients 64 and older who had undergone a series of HBOT treatments. Blood tests performed during the study showed that hyperbaric oxygen treatment reversed two common signs of biological aging:

The shortening of telomeres on chromosomes and the accumulation of senescent cells. Its importance is difficult to overstate. Telomeres are nucleotide sequences that protect the ends of chromosomes from damage or fusion with other chromosomes. A reduction in length of approximately 20 to 40 bases per year is associated with serious, life-threatening illnesses.

Preventing and reversing telomere shortening has long been considered the key to slowing down biological aging. Senescent cells inhibit cell proliferation. The accumulation of aging cells contributes to age-related diseases and conditions. According to previous studies in animals, eliminating them can reverse these conditions and diseases.

The “Holy Grail” of aging biology

The new study is part of a comprehensive aging research program underway in Israel. An earlier study, first published in 2020, showed that HBOT also improves cognitive function. “Having dedicated our HBOT research to exploring its impact on areas of brain function and age-related cognitive decline.

We have now discovered for the first time the biological effects of HBOT at the cellular level in healthy aging adults, Shai Efrati, director of the Sagol Center for Hyperbaric Medicine and Research at Yitzhak Shamir Medical Center and a co-author of the study, said in a press release. Efrati called telomere shortening “the ‘Holy Grail’ of aging biology” and said researchers are exploring a number of pharmacological and environmental interventions in hopes of allowing telomere lengthening.

Ifrati said: “The significant improvement in telomere length shown during and after these unique HBOT protocols provides the scientific community with a new basis for understanding whether aging is truly targeted and reversed at the basic cellular biological level.” He is an associate professor at the Sackler School of Medicine and the Sagol School of Neuroscience at Tel Aviv University.

How does the study was realized

Efrati co-authored the study with Dr. Amir Hadney, director of medical research at the Sagol Center for Hyperbaric Medicine and Research. Both focused on testing the effect of HBOT on telomere length and senescent cell concentrations in a non-pathogenic older adult population.

Efrati and Hadney conducted the prospective trial with 35 healthy, independent adults. None of the patients made changes to their lifestyle, diet, or medication during the study. Each received 60 daily HBOT sessions over the course of 90 days.

Whole blood samples were taken before treatment and again at sessions 30 and 60. Your blood was retested one to two weeks after the last HBOT session to assess telomere length and senescence of blood mononuclear cells. peripheral (PMBC).

The study found that some HBOT protocols induced regenerative effects. The length of some telomeres increased by more than 20%, while the number of senescent cells decreased by up to 37%.

Hadney said the groundbreaking study “opens the door to more research on the long-term cellular effects of HBOT in reversing the aging process.” He said that until the study, only lifestyle modifications and intense exercise decreased the ability to shorten telomere length.

“What’s worth noting in our study is that in just three months of HBOT, we were able to achieve such significant telomere elongation, at much higher rates than currently available interventions or lifestyle modifications,” said Dr. Hadney said.

Israeli doctors claim to “reverse” aging with a pure oxygen treatment study. Volunteers 65 and older ended up with sharp brains after the session in a special oxygen chamber, says Shai Efrati. A volunteer: ‘I came in healthy and came out of a tiger’.

Oxygen treatment

People inside hyperbaric chambers like those used by Israeli researchers for their studies on aging (Shutterstock). An Israeli doctor says that he has found a way to “reverse” aging in the brain and has successfully tested it on volunteers. He says that all this time the answer has been in front of our noses: oxygen.

Shai Efrati claims that she found that when healthy adults over 65 received special oxygen therapy, their cognitive function improved and so did brain tissue function. “It reverses aging,” said Ifrati, an associate professor at Tel Aviv University and a senior physician at Shamir Medical Center in Tzrifin, near Rishon Lezion. “It improves cognitive function and does not slow its decline.”

“This is the first time to my knowledge that there is a biological intervention that improves brain biology in the normal aging population. The decline that comes with aging does not need to be taken for granted,” Ifrati said. The times of Israel.

Hyperbaric chamber at the Sagol Center for Hyperbaric Medicine and Research at Shamir Medical Center (courtesy of the Sagol Center). One of the volunteers in his experiment, Avi Rabinovich, 69, said that he “came into this study healthy and left him like a tiger,” adding that his memory and cognition had improved.

Efrati recruited 63 people over the age of 65, took MRI scans, and tested their cognitive abilities. He then gave some of them a 60-day treatment, during which they spent 2 hours five times a week in a pressurized chamber, briefly breathing pure oxygen.

Professor Shai Efrati of the Sagol Center for Hyperbaric Medicine and Research at Shamir Medical Center (courtesy of the Sagol Center). At the end of the experiment, those who did not go to the hyperbaric chamber had similar MRI results as they did at the beginning, and had similar cognitive abilities. But Efrati reported a significant difference from those who received oxygen therapy and found improvements seen in the trials six months later.

“In these people, MRIs showed that the function of tissues in the brain, in areas associated with cognitive decline, had improved, and we also found a significant improvement in cognitive function,” he said, noting that the staff of evaluation did not know. the patients had received therapy.

Hyperbaric oxygen therapy

Ifrati’s study was published Wednesday in the journal Aging after a peer-reviewed study. A company he co-founded, Aviv Scientific, has been developing and marketing oxygen therapy programs for healthy adults since 2017 and began offering private sessions in the US last month. Aviv has a clinic in Florida and plans to open another in Dubai by the end of the year.

Norm O’Rourke, an expert on the mental health of older people outside the research, told The Times of Israel that he believes the study is “compelling.” Professor O’Rourke, from Ben Gurion University School of Public Health, praised the fact that the results used two different parameters, cognitive ability and the results of brain MRI scans. O’Rourke said: “It’s very interesting because they not only did the neurological tests, but they also have anatomical data on cerebral blood flow, so the two sets of findings are confirmed.”

Hillel Aviezer, a professor of psychology at the Hebrew University of Jerusalem, who was not involved in the study, commented: “This is an interesting study with some initially promising results. However, there is still room for caution when interpreting the results. In particular , the control group did not undergo any intervention, while the hyperbaric oxygen therapy (HBOT) group underwent a very intensive protocol of sessions for several days a week for several months.

“The structured weekly meetings of the HBOT group, the social interaction with the examiners and the natural placebo effect may have contributed to improved attention and speed of processing of results. However, the study provides a good step forward and offers hope for the future … “with more strictly controlled double-blind experimental designs.

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